Balks H J, Thim L, Conlon J M
Clinical Research Group for Gastrontestinal Endocrinology, University of Göttingen, FRG.
Clin Endocrinol (Oxf). 1988 Mar;28(3):261-9. doi: 10.1111/j.1365-2265.1988.tb01211.x.
Intravenous injection of pentagastrin (0.6 microgram/kg body wt) into two patients with metastatic carcinoid tumours evoked a severe carcinoid flush. Analysis by reverse-phase HPLC of acetone-extracts of peripheral blood taken from the patients during the flush indicated the presence of a peptide identified as the residues (1-33) fragment of the alpha-chain of haemoglobin. The peptide was not detected in blood taken from the patients immediately before stimulation of the flush or in the blood of healthy subjects after pentagastrin injection. The observation is interpreted as evidence that the pentagastrin-induce carcinoid flush is associated with the activation and possible release of a tumour protease that result in damage to erythrocytes.
对两名转移性类癌肿瘤患者静脉注射五肽胃泌素（0.6微克/千克体重）引发了严重的类癌潮红。通过反相高效液相色谱法对潮红期间从患者采集的外周血丙酮提取物进行分析，结果表明存在一种被鉴定为血红蛋白α链（1 - 33）残基片段的肽。在刺激潮红前立即从患者采集的血液中未检测到该肽，五肽胃泌素注射后健康受试者的血液中也未检测到。该观察结果被解释为五肽胃泌素诱导的类癌潮红与肿瘤蛋白酶的激活及可能释放有关，这会导致红细胞受损的证据。
