Richter G, Stöckmann F, Conlon J M, Creutzfeldt W
Gastroenterology. 1986 Sep;91(3):612-8. doi: 10.1016/0016-5085(86)90630-x.
The effect of a 550-kcal mixed meal and of an intravenous injection of pentagastrin (0.06 microgram/kg body wt) upon peripheral blood serotonin concentrations has been compared in 10 carcinoid patients with hepatic metastases and healthy subjects. The fasting concentrations of blood serotonin in the patients (range 790-4500 ng/ml) were elevated compared with healthy subjects (range 71-310 ng/ml; n = 15). Urinary output of 5-hydroxyindole acetic acid was elevated in 8 patients but was in the healthy range for 2 patients. The healthy subjects (n = 9) responded to food with an increase in blood serotonin (maximum rise over mean basal of 32% +/- 4%) that was significant at 60, 75, 90, and 105 min postcibal. All carcinoid patients responded to food with a comparable (25% +/- 11% over basal) rise in serotonin but the pattern of release was erratic. All patients with tumor metastases exhibited symptoms of the carcinoid flush after eating, but there was no correlation between occurrence and severity of the flush and occurrence and magnitude of the rise in serotonin. Intravenous pentagastrin evoked a flush in all carcinoid patients, but there was no significant increase in peripheral blood serotonin either in the patients or in healthy subjects.
在10例有肝转移的类癌患者和健康受试者中，比较了550千卡混合餐和静脉注射五肽胃泌素（0.06微克/千克体重）对外周血血清素浓度的影响。与健康受试者（范围71 - 310纳克/毫升；n = 15）相比，患者空腹血血清素浓度（范围790 - 4500纳克/毫升）升高。8例患者5-羟吲哚乙酸尿量升高，但2例患者处于健康范围。健康受试者（n = 9）进食后血血清素增加（最高超过平均基础值32%±4%），在进食后60、75、90和105分钟时具有统计学意义。所有类癌患者进食后血清素均有类似升高（超过基础值25%±11%），但释放模式不稳定。所有有肿瘤转移的患者进食后均出现类癌潮红症状，但潮红的发生和严重程度与血清素升高的发生和幅度之间无相关性。静脉注射五肽胃泌素使所有类癌患者出现潮红，但患者和健康受试者外周血血清素均无显著增加。
