高压氧疗法对日本职业或半职业橄榄球运动员膝关节二级内侧副韧带损伤恢复加速的影响：一项比较性非随机研究。

Effects of hyperbaric oxygen therapy on recovery acceleration in Japanese professional or semi-professional rugby players with grade 2 medial collateral ligament injury of the knee: A comparative non-randomized study.

作者信息

Yagishita Kazuyoshi, Enomoto Mitsuhiro, Takazawa Yuji, Fukuda Jun, Koga Hideyuki

机构信息

Hyperbaric Medical Center, Tokyo Medical and Dental University.

Clinical Center for Sports Medicine and Sports Dentistry, Tokyo Medical and Dental University.

出版信息

Undersea Hyperb Med. 2019;46(5):647-654.

PMID:31683363

Abstract

INTRODUCTION

The effects of hyperbaric oxygen (HBO2) therapy on sprains, ligament injuries, and muscle strains have been reported in several animal studies. In a dog model of compartment syndrome and in a rat contused skeletal muscle injury model, the significant effects of HBO2 therapy on the reduction of edema and muscle necrosis have been reported. In basic research HBO2 therapy stimulated fibroblast activity to improve the healing process. Because of this it expected that HBO2 therapy might improve focal edema and pain in the acute phase and accelerate the healing of injured tissues in athletes with a medial collateral ligament (MCL) injury of the knee. This study aimed to examine the short-term effects of HBO2 application subjectively, and the long-term effects of HBO2 therapy in Japanese professional or semi-professional rugby players with grade 2 MCL injury of the knee.

METHODS

Thirty-two professional or semi-professional rugby players with grade 2 MCL injury of the knee were investigated. First, in the HBO2 group (n=16), HBO2 therapy was performed during the acute phase. Visual analog scales (VASs) immediately before and after HBO2 therapy on the same day were compared. Next, we retrospectively evaluated the time to return to play in the HBO2 (n=16) and non-HBO2 (n=16) groups.

RESULTS

VAS scores for pain while walking immediately before and after HBO2 therapy on the same day were 37.4 ± 20.1 (mean ± standard deviation) and 32.4 ± 21.8, respectively (p⟨0.001). The VAS scores for pain while jogging were 50.7 ± 25.6 and 43.9 ± 25.0, respectively (p⟨0.001). The time to return to play was 31.4 ± 12.2 days in the HBO2 group and 42.1 ± 15.8 days in the non-HBO2 group, indicating a significant difference between the groups (p⟨0.05).

CONCLUSION

HBO2 therapy may reduce pain and accelerate the return to play in athletes with grade 2 MCL injury of the knee in this non-randomized study.

摘要

引言

多项动物研究报告了高压氧（HBO₂）疗法对扭伤、韧带损伤和肌肉拉伤的影响。在骨筋膜室综合征的犬模型和大鼠骨骼肌挫伤损伤模型中，已报告了HBO₂疗法对减轻水肿和肌肉坏死的显著效果。在基础研究中，HBO₂疗法刺激成纤维细胞活性以改善愈合过程。因此，预计HBO₂疗法可能改善急性期的局部水肿和疼痛，并加速膝关节内侧副韧带（MCL）损伤运动员受伤组织的愈合。本研究旨在主观检查HBO₂应用的短期效果，以及HBO₂疗法对日本职业或半职业橄榄球运动员膝关节2级MCL损伤的长期影响。

方法

对32名膝关节2级MCL损伤的职业或半职业橄榄球运动员进行了调查。首先，在HBO₂组（n = 16）中，在急性期进行HBO₂疗法。比较同一天HBO₂疗法前后的视觉模拟量表（VAS）评分。接下来，我们回顾性评估了HBO₂组（n = 16）和非HBO₂组（n = 16）恢复比赛的时间。

结果

同一天HBO₂疗法前后行走时疼痛的VAS评分分别为37.4±20.1（平均值±标准差）和32.4±21.8（p＜0.001）。慢跑时疼痛的VAS评分分别为50.7±25.6和43.9±25.0（p＜0.001）。HBO₂组恢复比赛的时间为31.4±12.2天，非HBO₂组为42.1±15.8天，表明两组之间存在显著差异（p＜0.05）。