Lu P P, Zhang N, Ma H M, Gu J H, Xu C L, Meng F S, Wang J L
School of Medicine and Life Sciences, Shandong Academy of Medical Sciences, University of Jinan, Jinan 250022, China.
Department of Education and Prevention, Shandong Cancer Hospital And Institute, Shangdong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2019 Nov 6;53(11):1104-1109. doi: 10.3760/cma.j.issn.0253-9624.2019.11.006.
To analyze the related factors of esophageal squamous cell carcinoma and precancerous lesions among residents aged 40-69 years old in rural areas of Shandong Province. In October 2018, 300 villages in 13 counties of the Shandong upper gastrointestinal cancerearly diagnosis and treatment projectin 2017 were selected as research areas, and 30 400 residents aged 40-69 were recruited in this study. The demographic characteristics, health status and lifestyle information were collected through the questionnaire survey, and endoscope iodine staining and indicative biopsy methods were used for cancer screening among eligible people.The multivariate logistic regression model was used to analyze the risk factors for esophageal cancer and precancerous lesions. The subjects in this study were (56.42±7.24) years old, including 13 193 males (43.40%).There were 936 cases of esophageal cancer and precancerous lesions (3.08%), including 521 males and 415 females.Compared with women, 40-49 years old, high level education, drinking tap water, regular intake of meat, eggs and milk, and family average annual income more than 30 000 RMB, men (1.90, 95: 1.65-2.19), 60-69 years old (5.28, 95: 4.11-7.30), primary school education or below (1.50, 95: 1.20-1.89), drinking groundwater (1.71, 95: 1.38-2.13), never eating meat, eggs and milk (1.48, 95: 1.22-1.80), and family average annual income less than 30 000 RMB (1.41, 95: 1.16-1.70) would increase the risk of esophageal cancer and precancerous lesions. The gender, age, educational level, annual household income, drinking water source, the frequency of eating meat, egg and milk were related to the occurrence of esophageal cancer and precancerous lesions among 40-69 years old residents in rural areas of Shandong Province.
分析山东省农村地区40 - 69岁居民食管鳞状细胞癌及癌前病变的相关因素。2018年10月，选取2017年山东省上消化道癌早诊早治项目中13个县的300个村庄作为研究区域，本研究招募了30400名40 - 69岁的居民。通过问卷调查收集人口学特征、健康状况和生活方式信息，并对符合条件的人群采用内镜碘染色及指示性活检方法进行癌症筛查。采用多因素logistic回归模型分析食管癌及癌前病变的危险因素。本研究对象年龄为(56.42±7.24)岁，其中男性13193名(43.40%)。食管癌及癌前病变936例(3.08%)，其中男性521例，女性415例。与女性相比，40 - 49岁、高学历、饮用自来水、经常摄入肉蛋奶且家庭年均收入超过30000元的男性(1.90,95%CI:1.65 - 2.19)、60 - 69岁(5.28,95%CI:4.11 - 7.30)、小学及以下学历(1.50,95%CI:1.20 - 1.89)、饮用地下水(1.71,95%CI:1.38 - 2.13)、从不食用肉蛋奶(1.48,95%CI:1.22 - 1.80)以及家庭年均收入低于30000元(1.41,95%CI:1.16 - 1.70)会增加食管癌及癌前病变的风险。性别、年龄、文化程度、家庭年收入、饮用水源、肉蛋奶食用频率与山东省农村地区40 - 69岁居民食管癌及癌前病变的发生有关。
