Guo L W, Liu S Z, Zhang M, Chen Q, Zhang S K, Sun X B
Henan Office for Cancer Control and Research, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China; Program Office for Cancer Screening in Urban China, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.
Henan Office for Cancer Control and Research, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Dec 10;38(12):1616-1619. doi: 10.3760/cma.j.issn.0254-6450.2017.12.006.
To investigate the effect of fried food intake on the pathogenesis of esophageal cancer and precancerous lesions. From 2005 to 2013, all the residents aged 40-69 years from 11 counties (cities) where cancer screening of upper gastrointestinal cancer had been conducted in rural areas of Henan province, were recruited as the subjects of study. Information on demography and lifestyle was collected. The residents under study were screened with iodine staining endoscopic examination and biopsy samples were diagnosed pathologically, under standardized criteria. Subjects with high risk were divided into the groups based on their different pathological degrees. Multivariate ordinal logistic regression analysis was used to analyze the relationship between the frequency of fried food intake and esophageal cancer and precancerous lesions. A total number of 8 792 cases with normal esophagus, 3 680 with mild hyperplasia, 972 with moderate hyperplasia, 413 with severe hyperplasia carcinoma in situ, and 336 cases of esophageal cancer were recruited. Results from multivariate logistic regression analysis showed that, when compared with those who did not eat fried food, the intake of fried food (<2 times/week: =1.60, 95%: 1.40-1.83; ≥2 times/week: =2.58, 95%: 1.98-3.37) appeared a risk factor for both esophageal cancer or precancerous lesions after adjustment for age, sex, marital status, educational level, body mass index, smoking and alcohol intake. The intake of fried food appeared a risk factor for both esophageal cancer and precancerous lesions.
为研究油炸食品摄入量对食管癌及癌前病变发病机制的影响。2005年至2013年，招募河南省农村地区已开展上消化道癌筛查的11个县（市）40 - 69岁的所有居民作为研究对象。收集人口统计学和生活方式信息。研究对象接受碘染色内镜检查筛查，并按照标准化标准对活检样本进行病理诊断。将高危受试者根据不同病理程度分组。采用多变量有序逻辑回归分析油炸食品摄入频率与食管癌及癌前病变之间的关系。共纳入8792例食管正常者、3680例轻度增生者、972例中度增生者、413例重度增生原位癌者及336例食管癌患者。多变量逻辑回归分析结果显示，与未食用油炸食品者相比，在调整年龄、性别、婚姻状况、教育水平、体重指数、吸烟和饮酒量后，油炸食品摄入量（<2次/周：比值比=1.60，95%置信区间：1.40 - 1.83；≥2次/周：比值比=2.58，95%置信区间：1.98 - 3.37）是食管癌或癌前病变的危险因素。油炸食品摄入量是食管癌和癌前病变的危险因素。
