Spadoni G L, Cianfarani S, Bernardini S, Vaccaro F, Galasso C, Manca Bitti M L, Costa F, Boscherini B
Department of Pediatrics, 2nd University of Rome, Italy.
Clin Pediatr (Phila). 1988 Oct;27(10):473-8. doi: 10.1177/000992288802701002.
Twelve-hour nocturnal GH secretion was studied in 30 children with familial short stature (FSS), constitutional growth delay (CGD), total growth hormone deficiency (TGHD), partial growth hormone deficiency (PGHD), or idiopathic short stature (ISS). No difference was observed between subjects with FSS and children with CGD. The mean 12-hour serum GH concentration was significantly lower in patients with TGHD (p less than 0.001), children with PGHD (p less than 0.01), and subjects with ISS (p less than 0.01) than in subjects with FSS and CGD. No overlap was observed between the range of mean concentration values of children with TGHD and that of subjects with FSS. A significant correlation was found between growth velocity expressed as SD from the mean for bone age and GH concentration (p less than 0.001). All patients with a growth velocity less than 3rd percentile for bone age showed a mean nocturnal concentration less than 4 ng/ml. These data suggest that evaluation of 12-hour spontaneous nocturnal GH secretion with GH sampling every 30 minutes can be usefully employed in the diagnosis of GH deficiency.
对30名患有家族性身材矮小（FSS）、体质性生长延迟（CGD）、完全性生长激素缺乏（TGHD）、部分性生长激素缺乏（PGHD）或特发性身材矮小（ISS）的儿童进行了12小时夜间生长激素分泌情况的研究。未观察到FSS患儿与CGD患儿之间存在差异。TGHD患者、PGHD患儿和ISS患者的12小时血清生长激素平均浓度显著低于FSS和CGD患者（p<0.001、p<0.01、p<0.01）。TGHD患儿的平均浓度值范围与FSS患儿的平均浓度值范围之间未观察到重叠。以骨龄均值的标准差表示的生长速度与生长激素浓度之间存在显著相关性（p<0.001）。所有骨龄生长速度低于第3百分位数的患者夜间平均浓度均低于4 ng/ml。这些数据表明，每30分钟采集一次生长激素样本，评估12小时自发性夜间生长激素分泌情况，可有效用于生长激素缺乏症的诊断。
