Popescu Cristian-Marian, Ursache Aurora Livia, Feketea Gavriela, Bocsan Corina, Jimbu Laura, Mesaros Oana, Edwards Michael, Wang Hongwei, Berceanu Iulia, Neaga Alexandra, Zdrenghea Mihnea
Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Babes str., 400012 Cluj-Napoca, Romania.
University of Agricultural Sciences and Veterinary Medicine, Calea Mănăștur 3-5, 400372 Cluj-Napoca, Romania.
Microorganisms. 2019 Nov 2;7(11):521. doi: 10.3390/microorganisms7110521.
Despite a plethora of studies demonstrating significant morbidity and mortality due to community-acquired respiratory viral (CRV) infections in intensively treated hematology patients, and despite the availability of evidence-based guidelines for the diagnosis and management of respiratory viral infections in this setting, there is no uniform inclusion of respiratory viral infection management in the clinical hematology routine. Nevertheless, timely diagnosis and systematic management of CRV infections in intensively treated hematology patients has a demonstrated potential to significantly improve outcome. We have briefly summarized the recently published data on CRV infection epidemiology, as well as guidelines on the diagnosis and management of CRV infections in patients intensively treated for hematological malignancies. We have also assessed available treatment options, as well as mentioned novel agents currently in development.
尽管大量研究表明,在接受强化治疗的血液学患者中,社区获得性呼吸道病毒(CRV)感染会导致严重的发病率和死亡率,而且在这种情况下已有基于证据的呼吸道病毒感染诊断和管理指南,但临床血液学常规中并未统一纳入呼吸道病毒感染管理。然而,对接受强化治疗的血液学患者的CRV感染进行及时诊断和系统管理已被证明有显著改善预后的潜力。我们简要总结了最近发表的关于CRV感染流行病学的数据,以及针对接受血液系统恶性肿瘤强化治疗患者的CRV感染诊断和管理指南。我们还评估了现有的治疗选择,并提及了目前正在研发的新型药物。