获得性瓣膜性心脏病患者免疫复合物的测定。
Determination of immune complexes in patients with acquired valvular heart disease.
作者信息
Petelenz T, Kozioł M, Friedek D, Słomińska-Petelenz T, Trzeciak J, Drazkiewicz U, Tustanowski J, Nolewajka E, Elertowicz M
机构信息
IIIrd Clinic of Cardiology, Silesian Academy of Medicine, Katowice-Ochojec, Poland.
出版信息
Cor Vasa. 1988;30(4):263-71.
The authors investigated the incidence of circulating immune complexes (CIC) in 52 patients with acquired valvular heart disease (VHD) and in 50 control blood donors. There was a statistically significant relationship between the CIC occurrence in patients with VHD and the presence of an active process in endocardium. However, no relation was found between the presence of CIC and heart operations, enucleation of palatine tonsils and the past history of rheumatic disease. The authors conclude that CIC investigation is a valuable diagnostic tool in patients with VHD and in those suspected of active infective endocarditis (IE). The obtained results confirm the presence of an immune factor in the etiopathogenesis of IE leading to VHD. However, they do not explain the implantation of the inflammatory process in the heart valves.
作者调查了52例获得性瓣膜性心脏病（VHD）患者和50名对照献血者循环免疫复合物（CIC）的发生率。VHD患者中CIC的出现与心内膜存在活跃病变之间存在统计学上的显著关系。然而，未发现CIC的存在与心脏手术、腭扁桃体摘除术及风湿性疾病既往史之间存在关联。作者得出结论，CIC检测对于VHD患者及疑似活动性感染性心内膜炎（IE）患者是一种有价值的诊断工具。所获结果证实了IE导致VHD的发病机制中存在免疫因素。然而，它们并未解释炎症过程在心脏瓣膜中的植入情况。
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