循环免疫复合物与严重脓毒症：感染持续时间作为主要决定因素。
Circulating immune complexes and severe sepsis: duration of infection as the main determinant.
作者信息
Pocidalo M A, Gibert C, Verroust P, Geniteau M, Adam C, Madec Y, Gaudebout C, Morel-Maroger L
出版信息
Clin Exp Immunol. 1982 Mar;47(3):513-9.
The relation between the duration of bacterial infection and circulating immune complexes (CIC) level was evaluated using the C1q binding assay in a group of patients with well defined clinical sepsis. Fifty-four patients with endocarditis and 35 with post-open heart surgery mediastinitis were prospectively studied over a period of 2 years. CIC were detected in 42% of patients studied. Interindividual variations were observed but it was found that the level of CIC increased statistically with time (P less than 0.001). CIC were statistically linked with cryoglobulinemia (P less than 0.001), rheumatoid factor (P less than 0.001) and a decreased CH50 (P less than 0.05). CIC were more frequent in patients with endocarditis (53%) than in patients with mediastinitis (24%). However, when the duration of the infection was taken into account the difference was no longer significant. No relation could be evidenced between the incidence of CIC and clinical symptoms including prognosis and renal signs. In our experience, determination of CIC does not have a critical clinical value.
在一组临床败血症明确的患者中，采用C1q结合试验评估细菌感染持续时间与循环免疫复合物（CIC）水平之间的关系。对54例心内膜炎患者和35例心脏直视手术后纵隔炎患者进行了为期2年的前瞻性研究。在所研究的患者中，42%检测到CIC。观察到个体间存在差异，但发现CIC水平随时间有统计学意义的升高（P<0.001）。CIC与冷球蛋白血症（P<0.001）、类风湿因子（P<0.001）及CH50降低（P<0.05）有统计学关联。心内膜炎患者中CIC更为常见（53%），高于纵隔炎患者（24%）。然而，当考虑感染持续时间时，差异不再显著。未发现CIC发生率与包括预后和肾脏体征在内的临床症状之间存在关联。根据我们的经验，CIC的测定没有关键的临床价值。
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