Prodanov K, Velkov Z, Tsakova L, Kemileva Z
Laboratory for Connective Tissue Study, Bulgarian Academy of Sciences, Sofia.
Cor Vasa. 1988;30(4):309-16.
The character and essence of changes taking place in the connective tissue matrix of the vascular wall under the effect of thymus deficiency are not well enough clarified. The aim of the study was to assess the content of collagen, elastin, total glucosamines, total glycoproteins, total nonfibrillar protein and total protein in the aorta total glycoproteins, total nonfibrillar protein and total protein in the aorta of adult thymectomized rats of the Wistar strain and in control animals over a 12-month post-thymectomy period. The amount of collagen and elastin augments both in connection with the aging process (after 2-4 months), and as a result of thymectomy. Glycoproteins show an increase starting from the third month in the controls, and from the fifth month in thymectomized animals. Glucosamines display a fluctuating decrease parallel to aging in either of the groups under study. The content of total protein and nonfibrillar protein reveals no differences worthy of notice. It is reasonable to assume the existence of a correlation between thymus activity and metabolism of the connective tissue components in the vascular wall of rats.
胸腺缺乏影响下血管壁结缔组织基质发生变化的特征和本质尚未得到充分阐明。本研究的目的是评估Wistar品系成年去胸腺大鼠和对照动物在去胸腺后12个月期间主动脉中胶原蛋白、弹性蛋白、总氨基葡萄糖、总糖蛋白、总非纤维状蛋白和总蛋白的含量。胶原蛋白和弹性蛋白的量在与衰老过程相关时（2 - 4个月后）以及去胸腺后都会增加。糖蛋白在对照组从第三个月开始增加，在去胸腺动物中从第五个月开始增加。氨基葡萄糖在两个研究组中均随衰老呈波动下降。总蛋白和非纤维状蛋白的含量没有显著差异。有理由认为大鼠血管壁中胸腺活性与结缔组织成分代谢之间存在相关性。
