Houdouin V, Dubus J-C
Inserm U 1149, équipe INSIGHT, service de pneumologie et d'allergologie pédiatrique, hôpital universitaire Robert-Debré, 48, boulevard Serrurier, 75019 Paris, France.
Unité de pneumo-allergologie pédiatrique, IRD, MEPHI, IHU-Méditerranée Infection, Aix Marseille Université, AP-HM, CHU de Timone-Enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France.
Arch Pediatr. 2019 Nov;26(8):487-491. doi: 10.1016/j.arcped.2019.10.007. Epub 2019 Nov 1.
Outdoor pollution is a complex mix of more than 200 air contaminants. Among these pollutants, ozone, nitrogen dioxide and fine particles may generate bronchial inflammation and hyperreactivity. The hypothesis that pollution contributes to the development of asthma in children is based on epidemiological, clinical and experimental data. Many risk factors during the in utero and postnatal period have been identified in the aetiology of childhood asthma. During pregnancy, outdoor pollution was identified as a causal factor of respiratory disease in neonatal cohort studies. Several epidemiological studies also demonstrate that outdoor pollution is a trigger of asthma exacerbations. This review aims to highlight the current knowledge on outdoor pollution and asthma.
室外污染是200多种空气污染物的复杂混合物。在这些污染物中，臭氧、二氧化氮和细颗粒物可能会引发支气管炎症和高反应性。污染导致儿童哮喘发病的假说基于流行病学、临床和实验数据。在儿童哮喘的病因中，已确定了宫内和出生后时期的许多风险因素。在新生儿队列研究中，室外污染被确定为孕期呼吸系统疾病的一个致病因素。多项流行病学研究还表明，室外污染是哮喘发作的一个诱因。本综述旨在突出关于室外污染与哮喘的当前知识。
