脂蛋白(a)作为预测急性心肌梗死患者冠状动脉侧支循环的标志物。

Lipoprotein(a) as a marker for predicting coronary collateral circulation in patients with acute myocardial infarction.

机构信息

Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, PR China.

Department of Cardiology, The People's Hospital of Tangxian County, Hebei Province, PR China.

出版信息

Per Med. 2020 Jan;17(1):67-78. doi: 10.2217/pme-2018-0127. Epub 2019 Nov 5.

DOI:10.2217/pme-2018-0127

PMID:31686591

Abstract

The aim of the present study was to examine the predictive value of lipoprotein(a) (Lp[a]) levels for coronary collateral circulation (CCC) in patients with acute myocardial infarction (AMI). A total of 409 consecutive patients with AMI were enrolled for this study. Patients were divided into two groups according to rentrop grades assessed by coronary angiography: bad (n = 277) and good CCC group (n = 132). Patients with bad CCC had a higher level of Lp(a) than that with good CCC (median Lp[a] 219.1 vs 122.0 mg/l). The area under the receiver-operating characteristic curves of Lp(a) in predicting bad CCC was 0.647 (95% CI: 0.592-0.702) with the cut-off value of 199.0 mg/l. Our data firstly suggested that Lp(a) might be a useful marker for CCC after AMI.

摘要

本研究旨在探讨脂蛋白(a)（Lp[a]）水平对急性心肌梗死（AMI）患者冠状动脉侧支循环（CCC）的预测价值。共纳入 409 例连续 AMI 患者。根据冠状动脉造影评估的Rentrop 分级，将患者分为两组：差的 CCC 组（n=277）和好的 CCC 组（n=132）。差的 CCC 患者的 Lp(a)水平高于好的 CCC 患者（中位数 Lp[a] 219.1 vs 122.0 mg/l）。Lp(a)预测差的 CCC 的受试者工作特征曲线下面积为 0.647（95%CI：0.592-0.702），截断值为 199.0 mg/l。我们的数据首次表明，Lp(a)可能是 AMI 后 CCC 的有用标志物。