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CCR5、MCP-1和维生素D受体基因多态性与乙肝病毒感染易感性相关。

CCR5, MCP-1 and VDR Gene Polymorphisms Are Associated with the Susceptibility to HBV Infection.

作者信息

Moudi Bita, Heidari Zahra, Mahmoudzadeh-Sagheb Hamidreza

机构信息

1Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

2Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

出版信息

Indian J Clin Biochem. 2019 Oct;34(4):407-417. doi: 10.1007/s12291-018-0772-8. Epub 2018 Jun 27.

DOI:10.1007/s12291-018-0772-8
PMID:31686727
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6801280/
Abstract

Genetic variants of chemokine and regulatory cytokines play functional roles in chronic HBV infection. The objective of the study, was to evaluate the association between the , -/, --/, -/, -/C SNPs and HBV susceptibility, in samples of Iranian populations. The , -/, -/, -/, -/ polymorphisms were analyzed by polymerase chain reaction and PCR-RFLP using 100 chronic HBV infected (HBV) patients, 40 spontaneously recovered HBV (SR) subjects and 100 healthy controls (C). Also, serum levels of protein were monitored. The study showed that the existence of -, - and - alleles significantly increased risk of chronic HBV infection. In addition, haplotype had a higher frequency in HBV patients than C and SR groups and might relate to the natural history of the infection. Statistical analysis indicated positive correlations between -/, -/, -/, -/ genotypes and serum levels of the CCR5, MCP-1 and VDR in HBV patients. According to the statistical analysis, significant associations with susceptibility to chronic HBV infection was observed with -/, -/, -/, -/ polymorphisms. In addition, no association of the SNP with the disease was found.

摘要

趋化因子和调节性细胞因子的基因变异在慢性乙型肝炎病毒（HBV）感染中发挥着功能性作用。本研究的目的是评估伊朗人群样本中，、- /、-- /、- /、- / C单核苷酸多态性（SNP）与HBV易感性之间的关联。采用聚合酶链反应（PCR）和PCR - 限制性片段长度多态性分析（PCR - RFLP）方法，对100例慢性HBV感染（HBV）患者、40例自发康复的HBV感染者（SR）和100例健康对照者（C）的、- /、- /、- /、- /多态性进行了分析。此外，还监测了血清蛋白水平。研究表明，-、-和-等位基因的存在显著增加了慢性HBV感染的风险。此外，单倍型在HBV患者中的频率高于C组和SR组，可能与感染的自然史有关。统计分析表明，HBV患者中- /、- /、- /、- /基因型与CCR5、MCP - 1和VDR血清水平呈正相关。根据统计分析，- /、- /、- /、- /多态性与慢性HBV感染易感性之间存在显著关联。此外，未发现SNP与该疾病有相关性。

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