白细胞介素-28B 基因多态性作为一种潜在的生物标志物与伊朗人群慢性牙周炎风险的相关性。
The association between interleukin-28B gene polymorphisms as a potential biomarker and the risk of chronic Periodontitis in an Iranian population.
机构信息
Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
出版信息
Head Face Med. 2017 Jun 27;13(1):16. doi: 10.1186/s13005-017-0148-y.
BACKGROUND
Chronic Periodontitis (CP) is a common inflammatory disease affects supporting tissues of the teeth and can lead to tooth loss. The objective of this study was to determine the relationship between polymorphisms in the IL-28B gene and chronic periodontitis in an Iranian population.
METHODS
Two hundred and ten CP patients and one hundred healthy subjects were enrolled in the present case-control study. The rs12979860 and rs8099917 SNPs were identified using RFLP and T-ARMS-PCR methods respectively.
RESULTS
SNP analysis revealed that the G allele of rs8099917 SNP and T allele of rs12979860 SNP increased susceptibility to CP compared to the A allele and C allele (p < 0.0001, OR = 2.712, CI = 1.783-4.126; p < 0.0001, OR = 2.538, CI = 1.784-3.613 respectively). In addition, the CT/GT, TT/GG and TT/GT haplotypes were predominant in CP patients and significantly associated with the increased risk of CP.
CONCLUSION
IL-28B polymorphisms may be useful predictive factors for chronic periodontitis and correlated to the susceptibility to CP infection in our population.
背景
慢性牙周炎（CP）是一种常见的炎症性疾病，影响牙齿的支持组织，可导致牙齿脱落。本研究旨在确定伊朗人群中 IL-28B 基因多态性与慢性牙周炎之间的关系。
方法
本病例对照研究纳入了 210 名 CP 患者和 100 名健康对照者。分别采用 RFLP 和 T-ARMS-PCR 方法检测 rs12979860 和 rs8099917 两个 SNP。
结果
SNP 分析显示，与 rs8099917 SNP 的 A 等位基因和 rs12979860 SNP 的 C 等位基因相比，G 等位基因和 T 等位基因增加了 CP 的易感性（p<0.0001，OR=2.712，CI=1.783-4.126；p<0.0001，OR=2.538，CI=1.784-3.613）。此外，CP 患者中 CT/GT、TT/GG 和 TT/GT 单倍型更为常见，与 CP 的发病风险增加显著相关。
结论
IL-28B 多态性可能是慢性牙周炎的有用预测因子，并与本人群 CP 感染的易感性相关。
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