School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China.
College of Chemistry, Beijing Normal University, Beijing, China.
Org Biomol Chem. 2019 Nov 28;17(44):9573-9577. doi: 10.1039/c9ob01649j. Epub 2019 Nov 5.
A series of chiral bisphosphine ligands were designed and synthesized based on single-handed quinoline oligoamide foldamers. The bisphosphine ligands can coordinate with Rh(cod)BF in a 1 : 1 stoichiometry and the resulted chiral Rh(i) catalysts were applied in the asymmetric hydrogenation of α-dehydroamino acid esters, in which excellent conversions and promising levels of enantioselectivity were achieved.
基于单手性喹啉寡酰胺折叠体，设计并合成了一系列手性双膦配体。双膦配体可以与 Rh(cod)BF 以 1:1 的化学计量比配位，得到的手性 Rh(i)催化剂被应用于α-去氢氨基酸酯的不对称氢化反应中，获得了优异的转化率和良好的对映选择性。
