Zhang Tao, Jiang Jun, Yao Lin, Geng Huiling, Zhang Xumu
School of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, China.
Chem Commun (Camb). 2017 Aug 15;53(66):9258-9261. doi: 10.1039/c7cc04045h.
A succinct and efficient protocol was developed for the synthesis of chiral aromatic ketones via asymmetric hydrogenation of β,β-disubstituted enones with rhodium catalysts based on chiral bisphosphine thiourea ligands. A series of substrates (17 examples) was smoothly catalyzed to afford the corresponding chiral aromatic ketones in high conversions (>99%) with excellent enantioselectivities (up to 96% ee).
开发了一种简洁高效的方法，用于通过基于手性双膦硫脲配体的铑催化剂对β,β-二取代烯酮进行不对称氢化来合成手性芳香酮。一系列底物（17个实例）被顺利催化，以高转化率（>99%）和优异的对映选择性（高达96% ee）得到相应的手性芳香酮。
