Suh Junghwan, Choi Han Saem, Kwon Ahreum, Chae Hyun Wook, Eom Soyong, Kim Ho-Seong
Department of Pediatrics, Severance Children's Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Epilepsy Research Institute, Yonsei University College of Medicine, Seoul, Korea.
J Pediatr Endocrinol Metab. 2019 Dec 18;32(12):1341-1350. doi: 10.1515/jpem-2019-0120.
Background Previous studies investigating the beneficial effects of exercise in type 1 diabetes mellitus (T1DM) are relatively insufficient compared to studies on type 2 diabetes mellitus (T2DM), due to the fear of hypoglycemia. Recently, several researchers have reported that combined aerobic and resistance exercise prevents hypoglycemia during and after exercise. Furthermore, exercise has been shown to have beneficial effects on the psychological status of patients with various diseases. The aim of this study was to evaluate the effect of combined aerobic and resistance exercise in adolescents with T1DM. Methods Thirty-five type 1 diabetic patients were enrolled, and subjects were divided into either an exercise group or a control group. Thirty patients (20 patients in the exercise group, 10 patients in the control group) completed the study. The exercise program was performed for 1 h at a time, once a week, for 12 weeks. Study parameters were evaluated at baseline and 3 months after baseline evaluation. Results Combined aerobic and resistance exercise better controlled the body mass index (BMI), and also improved maximum muscular strength and maximum exercise intensity. On psychological tests, subjects' attention and quality of life showed improving tendency, while their stress and behavioral problems diminished. The number of exercise events increased in the training group, while the daily total insulin dose and glycated hemoglobin (HbA1c) level showed no significant changes. Conclusions A 12-week structured exercise program consisting of aerobic and resistance exercises improves cardiovascular, neurocognitive and psychobehavioral functions, and positively helps lifestyle modification in patients with T1DM.
与2型糖尿病（T2DM）的研究相比，既往关于运动对1型糖尿病（T1DM）有益影响的研究相对不足，原因是担心低血糖。最近，一些研究人员报告称，有氧运动和抗阻运动相结合可预防运动期间及运动后的低血糖。此外，运动已被证明对患有各种疾病的患者的心理状态有有益影响。本研究的目的是评估有氧运动和抗阻运动相结合对T1DM青少年的影响。方法：招募了35名1型糖尿病患者，将受试者分为运动组或对照组。30名患者（运动组20名，对照组10名）完成了研究。运动计划每次进行1小时，每周一次，共进行12周。在基线和基线评估后3个月评估研究参数。结果：有氧运动和抗阻运动相结合能更好地控制体重指数（BMI），还能提高最大肌肉力量和最大运动强度。在心理测试中，受试者的注意力和生活质量呈改善趋势，而他们的压力和行为问题减少。训练组的运动事件数量增加，而每日总胰岛素剂量和糖化血红蛋白（HbA1c）水平无显著变化。结论：一项为期12周的由有氧运动和抗阻运动组成 的结构化运动计划可改善T1DM患者的心血管、神经认知和心理行为功能，并对生活方式的改变有积极帮助。
