Division of Hematology-Oncology, Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Open Biol. 2019 Nov 29;9(11):190187. doi: 10.1098/rsob.190187. Epub 2019 Nov 6.
The evolutionarily conserved Notch signalling pathway regulates the differentiation and function of mature T lymphocytes with major context-dependent consequences in host defence, autoimmunity and alloimmunity. The emerging effects of Notch signalling in T cell responses build upon a more established role for Notch in T cell development. Here, we provide a critical review of this burgeoning literature to make sense of what has been learned so far and highlight the experimental strategies that have been most useful in gleaning physiologically relevant information. We outline the functional consequences of Notch signalling in mature T cells in addition to key specific Notch ligand-receptor interactions and downstream molecular signalling pathways. Our goal is to help clarify future directions for this expanding body of work and the best approaches to answer important open questions.
Notch 信号通路在进化上保守，调节成熟 T 淋巴细胞的分化和功能，在宿主防御、自身免疫和同种异体免疫中具有主要的上下文依赖性后果。 Notch 信号在 T 细胞反应中的新兴作用建立在 Notch 在 T 细胞发育中更确定的作用基础上。在这里，我们对这一新兴文献进行了批判性回顾，以了解迄今为止的研究成果，并强调了在获取生理相关信息方面最有用的实验策略。我们概述了 Notch 信号在成熟 T 细胞中的功能后果，以及关键的特定 Notch 配体-受体相互作用和下游分子信号通路。我们的目标是帮助澄清这一不断发展的工作的未来方向，以及回答重要问题的最佳方法。
