Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA.
J Cell Biol. 2020 Jan 6;219(1). doi: 10.1083/jcb.201907022.
The serine glycine and one-carbon pathway (SGOCP) is a crucially important metabolic network for tumorigenesis, of unanticipated complexity, and with implications in the clinic. Solving how this network is regulated is key to understanding the underlying mechanisms of tumor heterogeneity and therapy resistance. Here, we review its role in cancer by focusing on key enzymes with tumor-promoting functions and important products of the SGOCP that are of physiological relevance for tumorigenesis. We discuss the regulatory mechanisms that coordinate the metabolic flux through the SGOCP and their deregulation, as well as how the actions of this metabolic network affect other cells in the tumor microenvironment, including endothelial and immune cells.
丝氨酸-甘氨酸和一碳代谢途径（SGOCP）是肿瘤发生中一个极其重要的代谢网络，具有出乎意料的复杂性，并对临床有影响。阐明该网络的调控机制是理解肿瘤异质性和治疗耐药性的基础机制的关键。在这里，我们通过关注具有促进肿瘤作用的关键酶和 SGOCP 的重要产物来综述其在癌症中的作用，这些产物与肿瘤发生的生理相关性有关。我们讨论了协调 SGOCP 代谢通量的调节机制及其失调，以及该代谢网络的作用如何影响肿瘤微环境中的其他细胞，包括内皮细胞和免疫细胞。
