Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, Institute of Translational Medicine, School of Basic Medicine, Henan University, Kaifeng, Henan 475004, P.R. China.
Int J Oncol. 2021 Feb;58(2):158-170. doi: 10.3892/ijo.2020.5158. Epub 2020 Dec 11.
Serine/glycine biosynthesis and one‑carbon metabolism are crucial in sustaining cancer cell survival and rapid proliferation, and of high clinical relevance. Excessive activation of serine/glycine biosynthesis drives tumorigenesis and provides a single carbon unit for one‑carbon metabolism. One‑carbon metabolism, which is a complex cyclic metabolic network based on the chemical reaction of folate compounds, provides the necessary proteins, nucleic acids, lipids and other biological macromolecules to support tumor growth. Moreover, one‑carbon metabolism also maintains the redox homeostasis of the tumor microenvironment and provides substrates for the methylation reaction. The present study reviews the role of key enzymes with tumor‑promoting functions and important intermediates that are physiologically relevant to tumorigenesis in serine/glycine/one‑carbon metabolism pathways. The related regulatory mechanisms of action of the key enzymes and important intermediates in tumors are also discussed. It is hoped that investigations into these pathways will provide new translational opportunities for human cancer drug development, dietary interventions, and biomarker identification.
丝氨酸/甘氨酸生物合成和一碳代谢对于维持癌细胞的存活和快速增殖至关重要，具有重要的临床意义。丝氨酸/甘氨酸生物合成的过度激活驱动肿瘤发生，并为一碳代谢提供一碳单位。一碳代谢是一种基于叶酸化合物化学反应的复杂循环代谢网络，为支持肿瘤生长提供必要的蛋白质、核酸、脂质和其他生物大分子。此外，一碳代谢还维持肿瘤微环境的氧化还原平衡，并为甲基化反应提供底物。本研究综述了丝氨酸/甘氨酸/一碳代谢途径中具有促进肿瘤功能的关键酶和与肿瘤发生生理相关的重要中间产物的作用。还讨论了肿瘤中关键酶和重要中间产物的相关调节机制。希望对这些途径的研究能为人类癌症药物开发、饮食干预和生物标志物鉴定提供新的转化机会。
