Necas E, Znojil V
Department of Pathophysiology, Faculty of General Medicine, Charles University, Prague, Czechoslovakia.
Exp Hematol. 1988 Nov;16(10):871-5.
The data collected in 107 experiments over 23 months have been pooled to indicate the responses of cellularity, stem cell (CFU-S) number, and CFU-S proliferation rate (CFU-S in S-phase) during early recovery of the bone marrow from 1.5 and 2.6 Gy irradiation. The bone marrow differentials and numbers of granulocyte-macrophage progenitors (CFC-GM) were determined after irradiation with 1.5 Gy. The CFU-S proliferation rate was examined also in mice irradiated with 3.5-5.0 Gy. The data are discussed in the light of various hypotheses about the functional organization of the CFU-S population. It is proposed that the control of the CFU-S production rate is primary rather than the control of CFU-S numbers.
在23个月内进行的107次实验中收集的数据已汇总，以表明在1.5和2.6 Gy照射后骨髓早期恢复期间细胞密度、干细胞（CFU-S）数量和CFU-S增殖率（处于S期的CFU-S）的反应。在用1.5 Gy照射后测定骨髓分类计数和粒细胞-巨噬细胞祖细胞（CFC-GM）数量。还在接受3.5 - 5.0 Gy照射的小鼠中检测了CFU-S增殖率。根据关于CFU-S群体功能组织的各种假设对数据进行了讨论。有人提出，对CFU-S产生率的控制是首要的，而不是对CFU-S数量的控制。
