Department of Molecular Virology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8677, Japan.
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo 173-8610, Japan;
Int J Med Sci. 2019 Sep 20;16(10):1366-1370. doi: 10.7150/ijms.32795. eCollection 2019.
Hepatitis A virus (HAV) infection is a major cause of acute hepatitis including acute liver failure. Hepatitis B infection (HBV) occurs worldwide, with the highest rates in Asian and African countries, and there are several reports that HAV infection may have a more severe clinical course in patients with chronic HBV infection. We previously demonstrated that Japanese miso extracts have inhibitory effects on HAV replication. In the present study, we examined the replication of HAV and HBV in a hepatocyte superinfection model and the inhibitory effects of Japanese miso extracts on both viruses. According to the results, HAV infection inhibited HBV replication in superinfected hepatocytes, and Japanese rice-koji miso extracts had inhibitory effects on HAV replication. Our findings provide useful information for clinicians in managing HAV infection in patients with chronic HBV infection.
甲型肝炎病毒（HAV）感染是急性肝炎的主要病因，包括急性肝衰竭。乙型肝炎病毒（HBV）感染在全球范围内发生，亚洲和非洲国家的发病率最高，有几份报告表明，在慢性 HBV 感染患者中，HAV 感染可能具有更严重的临床病程。我们之前证明日本味噌提取物对 HAV 复制具有抑制作用。在本研究中，我们在肝细胞再感染模型中检查了 HAV 和 HBV 的复制以及日本味噌提取物对这两种病毒的抑制作用。结果表明，HAV 感染抑制了再感染肝细胞中的 HBV 复制，日本米曲味噌提取物对 HAV 复制具有抑制作用。我们的研究结果为临床医生在管理慢性 HBV 感染患者的 HAV 感染方面提供了有用的信息。
