From the Department of Nuclear Medicine and PET/CT, Centre for Advanced Research in Imaging, Neuroscience and Genomics (CARING), Sir Ganga Ram Hospital, New Delhi, India.
Clin Nucl Med. 2020 Jan;45(1):74-75. doi: 10.1097/RLU.0000000000002802.
A 57-year-old man, on octreotide treatment for metastatic neuroendocrine tumor pancreas, was referred for whole-body Ga-DOTANOC PET/CT scan to evaluate treatment response. PET/CT scan revealed DOTANOC-avid lesion in the head of the pancreas with multiple tracer-avid soft tissue lesions in the liver, bilateral adrenal glands, and periportal lymph nodes. In addition, diffuse intense DOTANOC-avid mural thickening with intraluminal polypoidal mass formation was noted within the stomach causing significant luminal compromise, histopathological examination of which turned out be hypertrophic hypersecretory gastropathy. This case highlights the possibility of overexpression of somatostatin receptors in gastric hypertrophy, which has been little explored in literature.
一位 57 岁男性，因转移性胰腺神经内分泌肿瘤正在接受奥曲肽治疗，为评估治疗反应，进行了全身 Ga-DOTANOC PET/CT 扫描。PET/CT 扫描显示胰腺头部有 DOTANOC 摄取病灶，肝脏、双侧肾上腺和门脉周围淋巴结有多个示踪剂摄取的软组织病灶。此外，还发现胃内弥漫性强烈的 DOTANOC 摄取壁增厚，伴有腔内息肉样肿块形成，导致管腔明显狭窄，其组织病理学检查结果为肥厚性高分泌性胃病。本病例提示胃肥厚中生长抑素受体过度表达的可能性，这在文献中探讨较少。
