Kenedi P P
Diakonissen Hospital, Frankfurt/Main, FRG.
J Int Med Res. 1988 Jul-Aug;16(4):257-63. doi: 10.1177/030006058801600402.
This study determined the extent of the negative inotropic effect of either 200 mg standard release disopyramide given three times daily or 250 mg sustained release disopyramide given twice daily in 10 patients with normal and 10 with abnormal ventricular function. Assessment, by measurement of ejection fraction using 99mTc radionuclide ventriculography, was made 3 h after the first dose and again after 7 days' treatment, both at rest and after exercise. A similar reduction in ejection fraction occurred at rest and after exercise. Patients with an abnormal left ventricular function showed a greater decrease in ejection fraction compared with patients with normal left ventricular function, both at rest and after exercise. The extent of this reduction appeared to be correlated with the extent of left ventricular dysfunction. In no cases were these decreases statistically or clinically significant. No significant changes in heart volume occurred in any patient and none showed impaired clinical status. Plasma concentrations of disopyramide were also similar for both types of disopyramide in both groups of patients on days 1 and 7.
本研究确定了每日三次给予200mg标准释放型丙吡胺或每日两次给予250mg缓释型丙吡胺对10名心室功能正常和10名心室功能异常患者的负性肌力作用程度。使用99mTc放射性核素心室造影测量射血分数进行评估，在首次给药后3小时以及治疗7天后进行，包括静息时和运动后。静息时和运动后射血分数均出现类似程度的降低。左心室功能异常的患者与左心室功能正常的患者相比，静息时和运动后射血分数下降幅度更大。这种下降程度似乎与左心室功能障碍程度相关。在任何情况下，这些下降在统计学上或临床上均无显著意义。所有患者心脏容积均无显著变化，且均未出现临床状态受损。两组患者在第1天和第7天，两种类型丙吡胺的血浆浓度也相似。
