Arakawa M, Miwa H, Noda T, Kagawa K, Nishigaki K, Ito Y, Kawada T, Hirakawa S
Second Department of Internal Medicine, Gifu University School of Medicine, Japan.
Int J Clin Pharmacol Ther Toxicol. 1993 May;31(5):253-9.
Disopyramide, an antiarrhythmic drug, is known to impair cardiac function, but acute cardiac effects of conventional oral dose of disopyramide are not well known. To examine the extent of acute cardiac effects of daily oral dose of disopyramide, we gave 150 mg of disopyramide to thirteen patients with normal or impaired cardiac function, and observed cardiac function on an hourly basis for 3 hours after baseline period. The serum level of disopyramide reached a therapeutic level (2.0-5.0 micrograms/ml) mostly 1 hour after administration. Doppler-echocardiographically determined left ventricular ejection fraction, and the ratio of the peak early filling velocity to the peak atrial filling velocity in left ventricular inflow velocity remained unchanged throughout the experimental period. Other hemodynamic variables, such as blood pressure and heart rate remained unchanged. We conclude that daily oral dose of disopyramide appears to have no significant effects on cardiac function after administration. Disopyramide seems to be safe and may not be necessarily withheld from patients who need it, when hemodynamic variables are to be measured.
丙吡胺是一种抗心律失常药物，已知会损害心脏功能，但常规口服剂量丙吡胺的急性心脏效应尚不为人所知。为了研究每日口服剂量丙吡胺的急性心脏效应程度，我们给13名心脏功能正常或受损的患者服用了150毫克丙吡胺，并在基线期后每小时观察3小时的心脏功能。丙吡胺的血清水平大多在给药后1小时达到治疗水平（2.0 - 5.0微克/毫升）。在整个实验期间，多普勒超声心动图测定的左心室射血分数以及左心室流入速度中早期充盈峰值速度与心房充盈峰值速度之比保持不变。其他血流动力学变量，如血压和心率也保持不变。我们得出结论，每日口服剂量的丙吡胺给药后似乎对心脏功能没有显著影响。当需要测量血流动力学变量时，丙吡胺似乎是安全的，不一定需要不给需要它的患者使用。
