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新生儿期的性类固醇激素与六岁时的认知能力。

Neonatal sex-steroid hormones and cognitive abilities at six years.

作者信息

Jacklin C N, Wilcox K T, Maccoby E E

机构信息

Department of Psychology, University of Southern California, Los Angeles 90089-1061.

出版信息

Dev Psychobiol. 1988 Sep;21(6):567-74. doi: 10.1002/dev.420210607.

DOI:10.1002/dev.420210607
PMID:3169381
Abstract

Five sex-steroid hormones (testosterone, androstenedione, estradiol, estrone, and progesterone) were assayed in umbilical cord blood. Cognitive abilities were assessed as a part of a 6-year follow-up laboratory visit. Four subtests were given: reading, numbers, listening, and spatial ability. There were no significant differences between boys and girls in cognitive ability scores. Higher levels of perinatal androgens (testosterone and androstenedione) were significantly associated with low age-6 spatial ability in girls. Multiple regression analyses revealed a significant proportion of the variance in cognitive abilities in girls could be accounted for by testosterone and androstenedione. No significant predictions were found for boys. The finding of a stable inverse association between sex and effect of hormones on abilities is discussed.

摘要

对脐带血中的五种性类固醇激素(睾酮、雄烯二酮、雌二醇、雌酮和孕酮)进行了测定。作为6年随访实验室检查的一部分,对认知能力进行了评估。进行了四项子测试:阅读、数字、听力和空间能力。男孩和女孩的认知能力得分没有显著差异。围产期雄激素(睾酮和雄烯二酮)水平较高与女孩6岁时较低的空间能力显著相关。多元回归分析显示,女孩认知能力差异的很大一部分可由睾酮和雄烯二酮解释。未发现对男孩有显著预测作用。讨论了性别与激素对能力影响之间稳定的负相关关系这一发现。

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