Waldron D, Bowes K L, Kingma Y J, Cote K R
Department of Surgery, University of Alberta, Edmonton.
Gastroenterology. 1988 Nov;95(5):1388-94. doi: 10.1016/0016-5085(88)90377-0.
Forty-four severely constipated women and 16 (8 female, 8 male) asymptomatic volunteers underwent assessment of colon function by (a) clinical examination, (b) rectosigmoid intraluminal pressure recording, (c) colonic transit utilizing radiopaque markers, (d) anorectal manometry, and (e) rectosigmoid electrical activity. Constipated patients were characterized by (a) a greater volume and pressure of rectal distention required for both sensation and sphincter relaxation, (b) diminished basal and postmorphine motility indices only in the distal rectum, (c) delayed transit, and (d) an empty rectum when severely constipated. A neural abnormality affecting afferent nerves may be present in the rectum of female patients with severe idiopathic constipation. Delivery of stool to the rectum is impaired in these patients.
44名严重便秘的女性和16名（8名女性，8名男性）无症状志愿者接受了以下结肠功能评估：（a）临床检查；（b）直肠乙状结肠腔内压力记录；（c）使用不透X线标志物的结肠转运；（d）肛肠测压法；（e）直肠乙状结肠电活动。便秘患者的特征为：（a）感觉和括约肌松弛所需的直肠扩张体积和压力更大；（b）仅在直肠远端基础和吗啡后运动指数降低；（c）转运延迟；（d）严重便秘时直肠空虚。严重特发性便秘女性患者的直肠可能存在影响传入神经的神经异常。这些患者将粪便运送至直肠的过程受损。
