Corazziari E, Cucchiara S, Staiano A, Romaniello G, Tamburrini O, Torsoli A, Auricchio S
J Pediatr. 1985 Mar;106(3):379-82. doi: 10.1016/s0022-3476(85)80660-0.
Total gastrointestinal transit time (TGITT), frequency of defecation, and anorectal manometry were evaluated in 63 pediatric patients referred for chronic nonorganic constipation; in 39, segmental transit times of the right and left colon and rectum were also measured. TGITT was significantly longer in chronically constipated children than in matched normal controls. Although bowel frequency was highly significantly correlated with TGITT in patients with prolonged transit time, not all children with prolonged TGITT had reduced bowel frequency. Moreover, not all children with constipation had prolonged TGITT. In children with idiopathic chronic constipation, slowing of intestinal transit occurred most frequently at the level of the distal colon and rectum. Anorectal motility variables were not significantly different in children with functional chronic constipation and in normal children. Maximal resting and pressure and mean intrarectal distending volume causing threshold inhibition in constipated patients did not significantly differ from the control values. Therefore, anorectal manometry did not detect relevant motor abnormalities in constipated children.
对63名因慢性非器质性便秘前来就诊的儿科患者评估了全胃肠通过时间（TGITT）、排便频率和肛门直肠测压；对其中39名患者还测量了右半结肠、左半结肠和直肠的节段通过时间。慢性便秘儿童的TGITT显著长于匹配的正常对照。虽然在传输时间延长的患者中排便频率与TGITT高度显著相关，但并非所有TGITT延长的儿童排便频率都降低。此外，并非所有便秘儿童的TGITT都延长。在特发性慢性便秘儿童中，肠道传输减慢最常发生在远端结肠和直肠水平。功能性慢性便秘儿童和正常儿童的肛门直肠动力变量无显著差异。便秘患者的最大静息压和压力以及引起阈值抑制的平均直肠内扩张容积与对照值无显著差异。因此，肛门直肠测压未检测到便秘儿童有相关的运动异常。
