van Ackern K, Franke N, Peter K, Schmucker P
Acta Anaesthesiol Scand Suppl. 1979;71:71-6. doi: 10.1111/j.1399-6576.1979.tb05478.x.
In 12 patients with coronary artery disease, hypertensive periods during aortocoronary bypass surgery were treated with 1 MAC enflurane. The effect of enflurane on the major determinants of myocardial oxygen consumption was studied. Systolic arterial pressure was reduced to a level of about 120 mmHg (16 kPa). The heart rate diminished by 16.5%. The cardiac index during enflurane application was unchanged. Pulmonary artery wedge pressure was measured at short intervals and remained unchanged. The fall in arterial pressure and heart rate under unchanged preload produced a significant reduction in myocardial oxygen consumption as determined by calculation of the systolic wall tension and the tension time index. In five patients, the O2 content in coronary sinus blood was measured and the arterial-coronary sinus O2 difference was found to be diminished. In the concentration used, enflurane reduced the myocardial oxygen consumption of patients with coronary artery disease.
对12例冠心病患者在主动脉冠状动脉搭桥手术期间的高血压期使用1个最低肺泡有效浓度的恩氟烷进行治疗。研究了恩氟烷对心肌耗氧量主要决定因素的影响。收缩压降至约120 mmHg（16 kPa）水平。心率降低了16.5%。应用恩氟烷期间心脏指数未变。短时间间隔测量肺动脉楔压，其保持不变。在预负荷不变的情况下动脉压和心率下降，通过计算收缩期壁张力和张力时间指数可知心肌耗氧量显著降低。对5例患者测量了冠状窦血中的氧含量，发现动脉-冠状窦氧差减小。在所使用的浓度下，恩氟烷降低了冠心病患者的心肌耗氧量。
