Franke N, van Ackern K, Peter K
Acta Anaesthesiol Belg. 1979;30 Suppl:81-5.
In 12 patients with coronary artery disease, hypertensive period during aortocoronary bypass grafting were treated with enflurane. The effects of enflurane on the general hemodynamic and the major determinants of myocardial oxygen consumption were studied. Heart rate and systolic arterial pressure were significant reduced, cardiac index and pulmonary capillary wedge pressure remained unchanged. The calculated determinants of myocardial oxygen consumption decreased, as well as the measured arterial-coronary venous oxygen content difference. The authors conclude, that enflurane can reduce the afterload in patients with coronary heart disease.
对12例冠心病患者在主动脉冠状动脉旁路移植术的高血压期使用安氟醚进行治疗。研究了安氟醚对一般血流动力学及心肌耗氧量主要决定因素的影响。心率和收缩压显著降低，心脏指数和肺毛细血管楔压保持不变。计算得出的心肌耗氧量决定因素降低，测量的动脉 - 冠状静脉血氧含量差也降低。作者得出结论，安氟醚可降低冠心病患者的后负荷。
