Helal Iman E, Elsbaey Marwa, Zaghloul Ahmed M, Mansour El-Sayed S
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Nat Prod Res. 2021 Aug;35(15):2558-2563. doi: 10.1080/14786419.2019.1687471. Epub 2019 Nov 7.
A new C-linked chalcone-dihydrochalcone dimer, named dracidione, was isolated from the ethyl acetate extract of dragon's blood resin of Balf. f. Structure elucidation of the new compound was carried out by means of one- and two-dimensional NMR spectroscopy in addition to high resolution mass spectrometry. The unique structure incorporated a chalcone and a dihydrochalcone, which is reported for the first time from nature. Furthermore, dracidione showed moderate α-glucosidase inhibitory activity with IC= 40.27 µg/ml.
从南非多枝龙血树树脂的乙酸乙酯提取物中分离出一种新的C-连接查耳酮-二氢查耳酮二聚体，命名为血竭二酮。除高分辨率质谱外，还通过一维和二维核磁共振光谱对该新化合物进行了结构解析。这种独特的结构包含一个查耳酮和一个二氢查耳酮，这是首次从自然界中报道。此外，血竭二酮表现出中等程度的α-葡萄糖苷酶抑制活性，IC50 = 40.27μg/ml。
