Dermatology and Venereology Department, Al-Azhar Faculty of Medicine, Cairo, Egypt.
Dermatol Ther. 2020 Jan;33(1):e13155. doi: 10.1111/dth.13155. Epub 2019 Nov 14.
Onychomycosis is an important medical disorder affecting both health and quality of life of patients. This study was done to compare the efficacy of CO laser in combination with topical tioconazole versus CO laser only versus topical tioconazole alone in onychomycosis. A total of 120 patients with onychomycosis were randomly assigned to three groups. Group A patients were treated with fractional CO laser followed by topical tioconazole 28% for five sessions with 3 weeks interval. Group B patients were treated with only fractional CO laser for five sessions with 3 weeks interval. Group C patients were treated with only topical tioconazole 28% for 16 weeks. The clinical effect, KOH examination, and culture for the affected nails in the three groups were analyzed. One month after the last session, regarding clinical response, 55% showed complete clinical improvement in Group A versus 30% in Group B versus 25% in Group C with a significant difference in between. There was a significant difference between the three studied groups as regard KOH test and culture after treatment. Fractional CO laser combined with topical antifungal is a safe and effective treatment for onychomycosis.
甲真菌病是一种重要的医学疾病，影响患者的健康和生活质量。本研究旨在比较 CO2 激光联合外用酮康唑与单纯 CO2 激光治疗或单纯外用酮康唑治疗甲真菌病的疗效。共 120 例甲真菌病患者随机分为三组。A 组患者接受分束 CO2 激光治疗，然后外用酮康唑 28%，共 5 个疗程，间隔 3 周。B 组患者接受单纯分束 CO2 激光治疗，共 5 个疗程，间隔 3 周。C 组患者仅接受酮康唑 28%外用治疗 16 周。分析三组患者的临床疗效、KOH 检查和受影响指甲的培养情况。末次治疗后 1 个月，A 组完全临床缓解率为 55%，B 组为 30%，C 组为 25%，三组间差异有统计学意义。治疗后三组间 KOH 试验和培养有显著差异。分束 CO2 激光联合外用抗真菌药物是治疗甲真菌病的一种安全有效的方法。
