基于环境标准和优先药物风险分析的中国水环境中药物的优先排序。
Prioritization of pharmaceuticals in water environment in China based on environmental criteria and risk analysis of top-priority pharmaceuticals.
机构信息
State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.
State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.
出版信息
J Environ Manage. 2020 Jan 1;253:109732. doi: 10.1016/j.jenvman.2019.109732. Epub 2019 Nov 4.
Numerous studies have shown that a wide range of pharmaceuticals are present in the environment and many of their adverse biological effects on the aquatic ecosystem and human health are unknown. Due to the high population density and large number of pharmaceuticals produced and consumed in China, a systematic approach is needed to identify pharmaceuticals that require greater attention. The present study provides a ranking of pharmaceuticals in China in terms of their occurrence (O), persistence, bioaccumulation, and toxicity (PBT) based on the predicted environmental concentration (PEC). The total and partial ranking method implemented in the decision analysis by ranking techniques (DART) tool was used, which is an easy-to-use tool for the analysis of datasets. Using the DART approach, 10 pharmaceuticals were selected as priority compounds. These pharmaceuticals included antibiotics, anti-inflammatory and antilipidemic. In order to identify the characteristics of the priority pharmaceuticals, ecotoxicological endpoints were considered. The results of this study and the priority list facilitate the selection of candidate pollutants in future monitoring studies.
大量研究表明，环境中存在多种药品，其对水生生态系统和人类健康的许多不良生物学影响尚不清楚。由于中国人口密度高，药品生产和消费量大，因此需要采用系统的方法来确定需要重点关注的药品。本研究根据预测的环境浓度（PEC），对中国环境中存在的药品进行了基于其出现（O）、持久性、生物蓄积性和毒性（PBT）的排名。本研究采用决策分析中的排序技术（DART）工具中的总排序和部分排序方法，这是一种易于使用的数据集分析工具。使用 DART 方法，选择了 10 种药品作为优先化合物。这些药品包括抗生素、抗炎药和抗脂药。为了确定优先药品的特征，考虑了生态毒理学终点。本研究的结果和优先清单有助于在未来的监测研究中选择候选污染物。
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