State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.
State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.
Sci Total Environ. 2019 Mar 25;658:333-342. doi: 10.1016/j.scitotenv.2018.12.048. Epub 2018 Dec 5.
Pharmaceuticals have become "persistent" pollutants in the aquatic environment, due to their wide usage in daily life and their continuous release into the aquatic environment. Hence, prioritization and ranking lists are required to screen for target compounds as part of risk assessments. A ranking system based on three criteria, such as occurrence, exposure potential and ecological effects, was developed in this study for specific application to China. A total of 100 pharmaceuticals were selected as candidates based on the ranking system and available consumption data. These pharmaceuticals have been previously reported by wastewater treatment plants (WWTPs) in China. 13 pharmaceuticals were classified as priority pharmaceuticals, among which diclofenac, erythromycin, and penicillin G were highly prioritized. Due to their abuse, antibiotics contributed a majority to the priority pharmaceuticals among all therapeutic classes, indicating that antibiotics should be considered based on their behaviors in WWTPs. The pharmaceuticals ranking list achieved good applicability and will help to establish a focus for future monitoring and management of pharmaceuticals. It will also provide an important basis for both ecological risk assessment and pollution control of pharmaceuticals in the aquatic environment.
由于药品在日常生活中的广泛使用及其持续向水环境中的释放，药品已成为水环境中的“持久性”污染物。因此，需要进行优先级排序，以筛选作为风险评估一部分的目标化合物。本研究开发了一种基于三个标准（即出现、暴露潜力和生态效应）的排序系统，该系统专门针对中国进行了具体应用。根据该排序系统和可用的消费数据，共选择了 100 种药品作为候选药物。这些药品曾被中国的污水处理厂（WWTP）报道过。其中 13 种药品被归类为优先药品，其中双氯芬酸、红霉素和青霉素 G 被高度优先考虑。由于抗生素的滥用，在所有治疗类别中，抗生素对优先药品的贡献最大，这表明应根据抗生素在 WWTP 中的行为对其进行考虑。该药品排序清单具有良好的适用性，将有助于为未来药品的监测和管理建立重点，并为药品在水环境中的生态风险评估和污染控制提供重要依据。
