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胸腺瘤诱发的自身免疫性肝炎:一种罕见的副肿瘤综合征。

Thymoma-Induced Autoimmune Hepatitis: A Rare Paraneoplastic Syndrome.

作者信息

Stilwell Kendra T, Musick Sierra R, Cebe Katherine M, Morales-Cardona Amilcar L

机构信息

Internal Medicine, Brooke Army Medical Center, San Antonio, USA.

Pathology, Brooke Army Medical Center, San Antonio, USA.

出版信息

Cureus. 2019 Sep 12;11(9):e5637. doi: 10.7759/cureus.5637.

Abstract

Thymomas are rare neoplasms of the thymus and are often associated with immune-mediated paraneoplastic syndromes, most commonly, myasthenia gravis. The same underlying mechanism can produce antibodies to other self-antigens in various organ systems. Autoimmune hepatitis is a rare complication of thymoma. We present a 35-year-old healthy male, initially thought to have drug-induced liver injury, who was subsequently diagnosed with thymoma-induced autoimmune hepatitis, a rare syndrome of which only two previous cases have been reported.

摘要

胸腺瘤是胸腺的罕见肿瘤,常与免疫介导的副肿瘤综合征相关,最常见的是重症肌无力。相同的潜在机制可产生针对各种器官系统中其他自身抗原的抗体。自身免疫性肝炎是胸腺瘤的罕见并发症。我们报告一名35岁的健康男性,最初被认为患有药物性肝损伤,随后被诊断为胸腺瘤诱发的自身免疫性肝炎,这是一种罕见综合征,此前仅报道过两例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bc/6822890/06d28f1f1bea/cureus-0011-00000005637-i01.jpg

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