Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
J Neurol Sci. 2011 Sep 15;308(1-2):177-9. doi: 10.1016/j.jns.2011.05.038.
Thymomas are associated with paraneoplastic autoimmune diseases at a high frequency. It is rare that four paraneoplastic autoimmune disorders co-occur in a single patient. We describe a thymoma patient with diagnoses of myasthenia gravis, vitiligo, alopecia areata, and oral lichen planus associated with a thymoma. After thymectomy, the weakness, vitiligo, alopecia and mucocutaneous lesions were improving progressively, possibly implicating the thymoma in initiating these autoimmune conditions. We believe that this is the first report of this particular combination of multiple paraneoplastic syndromes associated with thymoma.
胸腺瘤常与副肿瘤自身免疫性疾病高频率相关。在单个患者中同时出现四种副肿瘤自身免疫性疾病十分罕见。我们描述了一例胸腺瘤患者，该患者被诊断患有重症肌无力、白癜风、斑秃和口腔扁平苔藓，这些疾病均与胸腺瘤相关。胸腺切除术后，肌无力、白癜风、脱发和黏膜损害逐渐改善，这可能提示胸腺瘤引发了这些自身免疫性疾病。我们认为，这是首例报道与胸腺瘤相关的这种特定的多种副肿瘤综合征组合。
