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通过延长持续胰岛素输注治疗危及生命的高钾血症。

Life threatening hyperkalemia treated with prolonged continuous insulin infusion.

作者信息

Awlad Thani Saif, Al Farsi Muzna, Al Omrani Sara

机构信息

Royal Hospital, Muscat, Oman.

出版信息

Int J Pediatr Adolesc Med. 2019 Sep;6(3):118-120. doi: 10.1016/j.ijpam.2019.04.001. Epub 2019 Apr 17.

DOI:10.1016/j.ijpam.2019.04.001
PMID:31700971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6824155/
Abstract

Hyperkalemia is a life threatening electrolyte imbalance that may be fatal if not treated appropriately. There are multiple medications used to treat hyperkalemia to lower it to a safe level. We report a case of a 4-month old infant with Pseudohypoaldosteronism who had cardiac arrest secondary to severe hyperkalemia of 12.3mmol/l. It was refractory to anti hyperkalemic medications that necessitated the transfer of the patient to a tertiary hospital for dialysis. The potassium level has dropped gradually to a normal level with continuous insulin infusion and dextrose for almost 12 hours that waved the need of the dialysis. This case highlights the effectiveness of prolonged continuous insulin infusion in treating life-threatening hyperkalemia especially in hospitals where there are no dialysis services available or until the dialysis is initiated.

摘要

高钾血症是一种危及生命的电解质失衡,如果治疗不当可能会致命。有多种药物用于治疗高钾血症,以将其降至安全水平。我们报告了一例4个月大的患有假性醛固酮减少症的婴儿,因严重高钾血症(血钾水平达12.3mmol/l)继发心脏骤停。抗高钾血症药物对此无效,因此需要将患者转至三级医院进行透析。通过持续输注胰岛素和葡萄糖近12小时,血钾水平逐渐降至正常,从而避免了透析的需要。该病例凸显了长时间持续输注胰岛素在治疗危及生命的高钾血症方面的有效性,尤其是在没有透析服务或尚未开始透析的医院。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4239/6824155/0cb029e510e8/egi10N5X27FND0.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4239/6824155/0170a345a09c/egi102PN0WPZKD.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4239/6824155/0cb029e510e8/egi10N5X27FND0.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4239/6824155/0170a345a09c/egi102PN0WPZKD.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4239/6824155/0cb029e510e8/egi10N5X27FND0.jpg

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本文引用的文献

1
Optimal Dose and Method of Administration of Intravenous Insulin in the Management of Emergency Hyperkalemia: A Systematic Review.静脉注射胰岛素治疗紧急高钾血症的最佳剂量和给药方法:一项系统评价
PLoS One. 2016 May 5;11(5):e0154963. doi: 10.1371/journal.pone.0154963. eCollection 2016.
2
Pseudohypoaldosteronism in a Neonate Presenting as Life-Threatening Hyperkalemia.一名新生儿表现为危及生命的高钾血症的假性醛固酮减少症。
Case Rep Endocrinol. 2016;2016:6384697. doi: 10.1155/2016/6384697. Epub 2016 Jan 19.
3
Insulin for the treatment of hyperkalemia: a double-edged sword?
胰岛素用于治疗高钾血症:一把双刃剑?
Clin Kidney J. 2014 Jun;7(3):239-41. doi: 10.1093/ckj/sfu049.
4
Bolus administration of intravenous glucose in the treatment of hyperkalemia: a randomized controlled trial.静脉推注葡萄糖治疗高钾血症的随机对照试验。
Nephron Physiol. 2014;126(1):1-8. doi: 10.1159/000358836. Epub 2014 Feb 22.
5
Hypokalemia and hyperkalemia in infants and children: pathophysiology and treatment.婴儿和儿童的低钾血症和高钾血症:病理生理学和治疗。
J Pediatr Health Care. 2013 Nov-Dec;27(6):486-96; quiz 497-8. doi: 10.1016/j.pedhc.2013.08.003.
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Continuous infusion of a standard combination solution in the management of hyperkalemia.持续输注标准组合溶液治疗高钾血症。
Nephrol Dial Transplant. 2011 Aug;26(8):2503-8. doi: 10.1093/ndt/gfq734. Epub 2011 Jan 10.
7
Management of patients with acute hyperkalemia.急性高钾血症患者的管理
CMAJ. 2010 Oct 19;182(15):1631-5. doi: 10.1503/cmaj.100461. Epub 2010 Sep 20.
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Management of severe hyperkalemia.严重高钾血症的管理
Crit Care Med. 2008 Dec;36(12):3246-51. doi: 10.1097/CCM.0b013e31818f222b.
9
Hyperkalemia revisited.再谈高钾血症。
Tex Heart Inst J. 2006;33(1):40-7.
10
Controversial issues in the treatment of hyperkalaemia.高钾血症治疗中的争议问题。
Nephrol Dial Transplant. 2003 Nov;18(11):2215-8. doi: 10.1093/ndt/gfg323.