Inskip Michael, Mavros Yorgi, Sachdev Perminder S, Fiatarone Singh Maria A
The University of Sydney Faculty of Health Sciences, Discipline of Exercise and Sports Science, Cumberland Campus, Lidcombe, NSW, 2141, Australia.
Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick, NSW, 2031, Australia.
Contemp Clin Trials Commun. 2019 Oct 12;16:100466. doi: 10.1016/j.conctc.2019.100466. eCollection 2019 Dec.
Lewy Body dementia (LBD) is the second most prevalent neurodegenerative dementia. This form of dementia is notable for an aggressive disease course consisting of a combination of cognitive, Parkinsonian, affective, and physiological symptoms that significantly increase morbidity and mortality, and decrease life expectancy in this population compared to more common dementias. Additionally, those diagnosed with LBD are often excluded from trials evaluating exercise in similar diseases such as Alzheimer's disease or Parkinson's disease due to the complexity and concurrency of motor and cognitive symptoms. Consequently, there is scarce research evaluating the effect of exercise on individuals with LBD.
The PRomoting Independence in Lewy Body Dementia through Exercise (PRIDE) trial is a novel non-randomised, crossover pilot study consisting of an 8-week wait-list usual care period, followed by an 8-week exercise intervention targeting progressive resistance and balance training. The trial aim is to evaluate the effect of exercise on the primary outcome of functional independence and secondary outcomes including cognitive, physical, psychosocial and quality of life measures in people living with LBD and their caregivers. The intervention involves 3 supervised 1-h sessions per week (24 sessions in total) administered by an Accredited Exercise Physiologist in a clinical facility at the University of Sydney in Lidcombe, Australia.
The PRIDE study is the first controlled trial to evaluate a robust exercise intervention within a LBD cohort and will provide crucial information required to inform robust future clinical trials.
Australia and New Zealand Trial Register (ANZCTR): ACTRN12616000466448; Key words: Lewy body; dementia; exercise; anabolic; functional independence.
路易体痴呆（LBD）是第二常见的神经退行性痴呆。这种痴呆形式以侵袭性病程为显著特征，其病程包含认知、帕金森氏症、情感和生理症状的组合，这些症状显著增加了发病率和死亡率，与更常见的痴呆相比，缩短了该人群的预期寿命。此外，由于运动和认知症状的复杂性和并发情况，被诊断为LBD的患者通常被排除在评估阿尔茨海默病或帕金森病等类似疾病运动效果的试验之外。因此，评估运动对LBD患者影响的研究很少。
通过运动促进路易体痴呆患者独立（PRIDE）试验是一项新型的非随机交叉试点研究，包括为期8周的等待名单常规护理期，随后是为期8周的运动干预，目标是进行渐进性抗阻和平衡训练。该试验的目的是评估运动对LBD患者及其照顾者功能独立性这一主要结局以及包括认知、身体、心理社会和生活质量指标在内的次要结局的影响。干预措施包括每周由一名注册运动生理学家在澳大利亚利德科姆的悉尼大学临床设施中进行3次1小时的监督训练（总共24次训练）。
PRIDE研究是首个评估LBD队列中有力运动干预措施的对照试验，将为未来有力的临床试验提供所需的关键信息。
澳大利亚和新西兰试验注册库（ANZCTR）：ACTRN12616000466448；关键词：路易体；痴呆；运动；合成代谢；功能独立性。
