Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, 950 W 28th Ave, Vancouver, BC V5Z 4H4, Canada.
Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway.
Nucleic Acids Res. 2020 Jan 8;48(D1):D87-D92. doi: 10.1093/nar/gkz1001.
JASPAR (http://jaspar.genereg.net) is an open-access database of curated, non-redundant transcription factor (TF)-binding profiles stored as position frequency matrices (PFMs) for TFs across multiple species in six taxonomic groups. In this 8th release of JASPAR, the CORE collection has been expanded with 245 new PFMs (169 for vertebrates, 42 for plants, 17 for nematodes, 10 for insects, and 7 for fungi), and 156 PFMs were updated (125 for vertebrates, 28 for plants and 3 for insects). These new profiles represent an 18% expansion compared to the previous release. JASPAR 2020 comes with a novel collection of unvalidated TF-binding profiles for which our curators did not find orthogonal supporting evidence in the literature. This collection has a dedicated web form to engage the community in the curation of unvalidated TF-binding profiles. Moreover, we created a Q&A forum to ease the communication between the user community and JASPAR curators. Finally, we updated the genomic tracks, inference tool, and TF-binding profile similarity clusters. All the data is available through the JASPAR website, its associated RESTful API, and through the JASPAR2020 R/Bioconductor package.
JASPAR（http://jaspar.genereg.net）是一个开放获取的数据库，其中包含经过精心整理的、非冗余的转录因子（TF）结合谱，以位置频率矩阵（PFM）的形式存储，涵盖了六个分类群中的多个物种的 TF。在 JASPAR 的第 8 个版本中，CORE 集合已经扩展了 245 个新的 PFM（169 个用于脊椎动物，42 个用于植物，17 个用于线虫，10 个用于昆虫，7 个用于真菌），并且更新了 156 个 PFM（125 个用于脊椎动物，28 个用于植物，3 个用于昆虫）。与前一版本相比，这些新的 PFM 代表了 18%的扩展。JASPAR 2020 还包含了一个新的未经验证的 TF 结合谱集合，我们的编辑在文献中没有找到这些集合的正交支持证据。这个集合有一个专门的网络表单，用于让社区参与到未经验证的 TF 结合谱的编辑中。此外，我们创建了一个问答论坛，以方便用户社区和 JASPAR 编辑之间的交流。最后，我们更新了基因组轨迹、推理工具和 TF 结合谱相似性聚类。所有的数据都可以通过 JASPAR 网站、其相关的 RESTful API 以及 JASPAR2020 R/Bioconductor 包获得。
