Andrews J C, Knutsen C, Smith P, Prieskorn D, Crudip J, Klevering J, Ensminger W D
Department of Radiology, Upjohn Center for Clinical Pharmacology, University of Michigan Medical School, Ann Arbor 48109.
Invest Radiol. 1988 Jul;23(7):524-6. doi: 10.1097/00004424-198807000-00008.
A simple method to obtain long-term access to the biliary tree in dogs and pigs is presented. In ten dogs and four pigs, a cholecystectomy was performed, the cystic duct isolated, and a catheter inserted into the cut end of the cystic duct. The catheter was connected to a subcutaneous infusion port, producing a closed, internal system to allow long-term access. The catheter placement was successful in three of the pigs and all of the dogs. Thirty-five cholangiograms were obtained in the 13 subjects by accessing the port with a 20 gauge Huber needle and injecting small amounts (4-10 mL) of contrast under fluoroscopic control. Cholangiograms were obtained up to four months after catheter placement without evidence for catheter failure or surgically induced changes in the biliary tree. This model provides a simple, reliable means to obtain serial cholangiograms in a research setting.
本文介绍了一种在犬和猪身上获得长期胆道通路的简单方法。对10只犬和4头猪进行胆囊切除术，分离出胆囊管，并将一根导管插入胆囊管的断端。将导管连接到一个皮下输液端口，形成一个封闭的内部系统，以实现长期通路。导管放置在3头猪和所有犬身上均获成功。通过用20号休伯针穿刺端口并在透视控制下注入少量（4 - 10 mL）造影剂，在13只实验对象身上共获得了35张胆管造影照片。在导管放置后长达四个月的时间里均可获得胆管造影照片，且未发现导管故障或手术引起的胆道树改变的迹象。该模型为在研究环境中获得系列胆管造影照片提供了一种简单、可靠的方法。
