通过锌催化的脱羧 A 反应，实现 N-杂环 1,6-烯炔的发散合成。
Divergent synthesis of N-heterocyclic 1,6-enynes through a zinc-catalyzed decarboxylative A reaction.
机构信息
Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.
College of Chemistry and Chemical Engineering and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen 361005, China.
出版信息
Chem Commun (Camb). 2019 Dec 7;55(94):14170-14173. doi: 10.1039/c9cc06985b. Epub 2019 Nov 8.
A zinc-catalyzed decarboxylative A reaction of cyclic amino acids, α,β-unsaturated aldehydes and terminal alkynes has been developed. A series of functionalized N-heterocyclic 1,6-enynes have been successfully obtained with excellent regioselectivities through this novel approach. In addition, the utility of this straightforward process is demonstrated by the preparation of a polycyclic nitrogen-containing heterocyclic compound.
发展了一种锌催化的环状氨基酸、α,β-不饱和醛和末端炔烃的脱羧 A 反应。通过这种新方法，成功地获得了一系列具有优异区域选择性的功能化 N-杂环 1,6-烯炔。此外，该直接方法的实用性通过制备多环含氮杂环化合物得到了证明。
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