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支原体感染介导耐多药细胞系对硫普罗宁的敏感性：一个警示故事。

Mycoplasma Infection Mediates Sensitivity of Multidrug-Resistant Cell Lines to Tiopronin: A Cautionary Tale.

出版信息

J Med Chem. 2020 Feb 13;63(3):1434-1439. doi: 10.1021/acs.jmedchem.9b00484. Epub 2020 Feb 4.

DOI:10.1021/acs.jmedchem.9b00484
PMID:31702923
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7448223/
Abstract

We previously reported that some, but not all, multidrug-resistant cells that overexpressed various drug-resistance transporters were collaterally sensitive to tiopronin. In recent follow-up studies, we discovered that sensitivity to tiopronin in the original study was mediated by infection of the cells by a human-specific strain of mycoplasma. These results strongly support the need to constantly monitor cells for mycoplasma infection and keep stored samples of all cells that are used for studies.

摘要

我们之前曾报道过，一些但不是所有过度表达各种药物转运蛋白的多药耐药细胞对硫普罗宁具有交叉敏感性。在最近的后续研究中，我们发现，原始研究中对硫普罗宁的敏感性是由细胞感染人特异性支原体菌株引起的。这些结果强烈支持需要不断监测细胞是否感染支原体，并保存用于研究的所有细胞的储存样本。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f8/7448223/96c0a04042fe/nihms-1610693-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f8/7448223/8cc1c793c5e2/nihms-1610693-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f8/7448223/c57ac2422488/nihms-1610693-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f8/7448223/96c0a04042fe/nihms-1610693-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f8/7448223/8cc1c793c5e2/nihms-1610693-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f8/7448223/c57ac2422488/nihms-1610693-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f8/7448223/96c0a04042fe/nihms-1610693-f0003.jpg

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