Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.
Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina.
Am J Physiol Heart Circ Physiol. 2019 Dec 1;317(6):H1254-H1257. doi: 10.1152/ajpheart.00642.2019. Epub 2019 Nov 8.
The adaptive immune response has recently emerged as an important factor in a wide variety of cardiovascular disorders including atherosclerosis, hypertension, cardiac remodeling, and heart failure; however, its role is not fully understood. Since an assortment of innate responsive cells, e.g., neutrophils and monocytes/macrophages, coordinate with adaptive immunity, e.g., T cells, dendritic cells, and B cells, the temporal response and descriptions pertinent to the cellular phenotype and inflammation processes, in general, need additional investigation, clarification, and consensus particularly in cardiovascular disease. This Perspectives article reviews the contributions of 15 articles (including 7 reviews) published in the in response to the Call for Papers: Adaptive Immunity in Cardiovascular Disease. Here, we summarize the crucial reported findings at the cardiac, vascular, immune, and molecular levels and discuss the translational feasibility and benefits of future prospective research into the adaptive immune response. Readers are encouraged to evaluate the data and learn from this collection of novel studies.
适应性免疫反应最近已成为多种心血管疾病的重要因素，包括动脉粥样硬化、高血压、心脏重构和心力衰竭；然而，其作用尚未完全阐明。由于各种先天反应细胞，例如中性粒细胞和单核细胞/巨噬细胞，与适应性免疫，例如 T 细胞、树突状细胞和 B 细胞，协调，因此需要对与细胞表型和炎症过程相关的时间反应和描述进行额外的研究、澄清和共识，特别是在心血管疾病中。本文回顾了在回应论文征集：心血管疾病中的适应性免疫反应而发表在《循环研究》中的 15 篇文章（包括 7 篇综述）的贡献。在这里，我们总结了心脏、血管、免疫和分子水平上的重要报告结果，并讨论了未来对适应性免疫反应进行前瞻性研究的转化可行性和益处。鼓励读者评估这些数据，并从这些新研究中学习。
