Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia; Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia; Department of Endocrinology, The Royal Children's Hospital, Parkville, Victoria, Australia.
Trends Endocrinol Metab. 2020 May;31(5):378-389. doi: 10.1016/j.tem.2020.01.008. Epub 2020 Feb 8.
Obesity, a chronic inflammatory disease, is the most prevalent modifiable risk factor for cardiovascular disease. The mechanisms underlying inflammation in obesity are incompletely understood. Recent developments have challenged the dogma of immunological memory occurring exclusively in the adaptive immune system and show that the innate immune system has potential to be reprogrammed. This innate immune memory (trained immunity) is characterized by epigenetic and metabolic reprogramming of myeloid cells following endogenous or exogenous stimulation, resulting in enhanced inflammation to subsequent stimuli. Trained immunity phenotypes have now been reported for other immune and non-immune cells. Here, we provide a novel perspective on the putative role of trained immunity in mediating the adverse cardiovascular effects of obesity and highlight potential translational pathways.
肥胖是一种慢性炎症性疾病，是心血管疾病最常见的可改变的危险因素。肥胖症中炎症的发生机制尚不完全清楚。最近的研究进展挑战了免疫记忆仅发生在适应性免疫系统中的教条，并表明先天免疫系统有可能被重新编程。这种先天免疫记忆（训练有素的免疫）的特征是内源性或外源性刺激后髓样细胞的表观遗传和代谢重编程，导致对后续刺激的炎症增强。现在已经报道了其他免疫和非免疫细胞的训练免疫表型。在这里，我们提供了一个新的视角，探讨训练有素的免疫在介导肥胖的不良心血管效应中的潜在作用，并强调了潜在的转化途径。
