Rohr J, Eick S, Zeeck A, Reuschenbach P, Zähner H, Fiedler H P
Universität Göttingen, Institut für Organische Chemie, FRG.
J Antibiot (Tokyo). 1988 Aug;41(8):1066-73. doi: 10.7164/antibiotics.41.1066.
Tetracenomycins B3 and D3, besides tetracenomycin D (D1), were produced by a blocked mutant of the elloramycin producer Streptomyces olivaceus TU 2353. The compounds were isolated as red powders, and their structures were elucidated by comparing their physicochemical data with those of the known tetracenomycins A2, B1, B2, D and E. Tetracenomycin B3 (2), the main compound, and tetracenomycin D (3) were antibiotically inactive against Gram-positive and Gram-negative bacteria, whereas tetracenomycin D3 (1) showed a moderate activity against Bacillus subtilis and Arthrobacter aurescens. Tetracenomycin B3 (2) is the key intermediate where the biosynthesis of the elloramycins branches off from the line leading to tetracenomycin C (5) as the final product of the tetracenomycin biosynthesis branch.
除了四环素霉素D（D1）外，四环素霉素B3和D3是由埃洛霉素产生菌橄榄链霉菌TU 2353的一个阻断突变体产生的。这些化合物被分离为红色粉末，通过将它们的物理化学数据与已知的四环素霉素A2、B1、B2、D和E的物理化学数据进行比较来阐明其结构。主要化合物四环素霉素B3（2）和四环素霉素D（3）对革兰氏阳性菌和革兰氏阴性菌没有抗菌活性，而四环素霉素D3（1）对枯草芽孢杆菌和金黄节杆菌显示出中等活性。四环素霉素B3（2）是关键中间体，在该中间体处，埃洛霉素的生物合成从导致四环素霉素C（5）作为四环素霉素生物合成分支的最终产物的路线分支出来。
