Department of Cardiology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Genes (Basel). 2019 Nov 7;10(11):908. doi: 10.3390/genes10110908.
Lower levels of physical activity (PA) have been associated with increased risk of cardiovascular disease. Worldwide, there is a shift towards a lifestyle with less PA, posing a serious threat to public health. One of the suggested mechanisms behind the association between PA and disease development is through systemic inflammation, in which circulating blood cells play a pivotal role. In this study we investigated the relationship between genetically determined PA and circulating blood cells. We used 68 single nucleotide polymorphisms associated with objectively measured PA levels to perform a Mendelian randomization analysis on circulating blood cells in 222,645 participants of the UK Biobank. For inverse variance fixed effects Mendelian randomization analyses, < 1.85 × 10 (Bonferroni-adjusted -value of 0.05/27 tests) was considered statistically significant. Genetically determined increased PA was associated with decreased lymphocytes (β = -0.03, SE = 0.008, = 1.35 × 10) and decreased eosinophils (β = -0.008, SE = 0.002, = 1.36 × 10). Although further mechanistic studies are warranted, these findings suggest increased physical activity is associated with an improved inflammatory state with fewer lymphocytes and eosinophils.
体力活动水平较低与心血管疾病风险增加有关。在全球范围内，人们的生活方式正朝着体力活动减少的方向转变，这对公众健康构成了严重威胁。体力活动与疾病发展之间关联的一个潜在机制是全身炎症，其中循环血液细胞起着关键作用。在这项研究中，我们调查了遗传决定的体力活动与循环血液细胞之间的关系。我们使用了 68 个与客观测量的体力活动水平相关的单核苷酸多态性，对英国生物库 222645 名参与者的循环血液细胞进行孟德尔随机分析。对于逆方差固定效应孟德尔随机分析， < 1.85 × 10 （Bonferroni 调整后的 0.05/27 次检验的 值）被认为具有统计学意义。遗传决定的体力活动增加与淋巴细胞减少（β = -0.03，SE = 0.008， = 1.35 × 10）和嗜酸性粒细胞减少（β = -0.008，SE = 0.002， = 1.36 × 10）有关。尽管需要进一步的机制研究，但这些发现表明，体力活动增加与炎症状态改善有关，淋巴细胞和嗜酸性粒细胞减少。
