孟德尔随机化研究表明体力活动与肺癌之间不存在因果关系。
Mendelian randomization study indicates lack of causal relationship between physical activity and lung cancer.
机构信息
Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, China.
State Key Laboratory of Oncology in South China, Guangzhou, 510060, China.
出版信息
J Cancer Res Clin Oncol. 2021 Jan;147(1):177-181. doi: 10.1007/s00432-020-03409-1. Epub 2020 Sep 28.
BACKGROUND
Previous researches have indicated physical activity (PA) may be associated with lower risk of lung cancer. However, causal relationship between PA and risk of lung cancer is not clear. We aimed to inspect the causal effect of PA on lung cancer.
METHODS
We analyzed summary data of accelerator-measured PA and lung cancer from the genome-wide association study (GWAS) using two-sample Mendelian randomization (MR) method. We obtained summary data of accelerator-measured PA from UK Biobank, data of lung cancer patients from Consortium and International Lung Cancer Consortium (ILCCO) to investigate possible causal effect of PA on lung cancer.
RESULTS
According to result of MR using inverse variance weighted method (IVW), we found that genetically predicted higher PA level did not causally decrease risk of lung cancer (OR 0.95, 95% CI 0.88-1.03, p = 0.238). Results of MR-Egger and weighted median method were consistent with IVW method.
CONCLUSION
Our mendelian randomization study showed that genetically higher PA is not causally associated with risk of lung cancer. More researches are needed to investigate relationship between PA and lung cancer.
背景
先前的研究表明，身体活动（PA）可能与较低的肺癌风险相关。然而，PA 与肺癌风险之间的因果关系尚不清楚。我们旨在检查 PA 对肺癌的因果影响。
方法
我们使用两样本 Mendelian 随机化（MR）方法，分析了来自 UK Biobank 的加速度计测量的 PA 和肺癌的汇总数据，以及来自 Consortium 和国际肺癌联盟（ILCCO）的肺癌患者数据，以调查 PA 对肺癌的可能因果作用。
结果
根据逆方差加权法（IVW）的 MR 结果，我们发现，遗传预测的更高的 PA 水平并不能使肺癌风险降低（OR 0.95，95%CI 0.88-1.03，p=0.238）。MR-Egger 和加权中位数法的结果与 IVW 方法一致。
结论
我们的 Mendelian 随机化研究表明，遗传上较高的 PA 与肺癌风险无因果关系。需要进一步的研究来探讨 PA 与肺癌之间的关系。
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