Department of Respiratory and Critical Care Medicine, Taizhou People's Hospital, 210 Yingchun Road, Taizhou, Jiangsu, 225300, People's Republic of China.
Department of Nuclear Medicine, Taizhou People's Hospital, 210 Yingchun Road, Taizhou, Jiangsu, 225300, People's Republic of China.
BMC Pulm Med. 2019 Nov 8;19(1):205. doi: 10.1186/s12890-019-0974-8.
The critical management of advanced non-small-cell lung carcinoma (NSCLC), especially when complicated by severe airway stenosis, is difficult and often leads to high clinical risks and medical costs.
A 51-year-old previously healthy male was admitted to the Department of Respiratory and Critical Care Medicine, Taizhou People's Hospital, in November 2018 for haemoptysis and difficulty breathing during a 15-d period. Following admission, chest computed tomography (CT) showed a large mass in the left hilum with atelectasis in the left upper lobe and obstructive pneumonia in the left lower lobe. Bronchoscopy revealed that the lesions occurred in the distal segment of the left main trachea, with occlusion of the left upper bronchus and significant narrowing of the lower bronchus. A basal mucosal biopsy of the lump tissue was performed after haemostasis treatment with sub-plasma coagulation (APC), and squamous lung carcinoma was confirmed. Following the final diagnosis, the patient was successfully treated with implantation of I radioactive seeds via transbronchial needle aspiration (c-TBNA) combined with chemotherapy.
We believe that implantation of I radioactive seeds via c-TBNA is an effective treatment for patients with advanced lung cancer and those presenting with severe and mixed main bronchus stenosis.
晚期非小细胞肺癌（NSCLC）的治疗极具挑战性，特别是当伴有严重气道狭窄时，往往会导致较高的临床风险和医疗费用。
一位 51 岁的既往健康男性于 2018 年 11 月因咯血和呼吸困难入住泰州市人民医院呼吸与危重症医学科。入院后，胸部 CT 显示左肺门有一个大肿块，左上叶肺不张，左下叶阻塞性肺炎。支气管镜检查显示病变位于左主支气管远端，左上支气管闭塞，下支气管明显狭窄。在使用亚等离子凝固（APC）进行止血治疗后，对肿块组织进行基底黏膜活检，确诊为鳞状细胞肺癌。明确诊断后，患者成功接受了经支气管针吸活检（c-TBNA）联合化疗植入 I 放射性粒子治疗。
我们认为，c-TBNA 植入 I 放射性粒子治疗晚期肺癌和严重混合性主支气管狭窄患者是一种有效的治疗方法。
