Pediatric Research and Clinical Center for Infectious Diseases, Popov Str.9, Saint Petersburg, Russia, 197022 and North Western State Medical University named after I.I. Mechnikov, Kirochnaya Str. 41, St Petersburg, Russia, 191015.
Rostropovich Vishnevskaya Foundation and Georgetown University Hospital Department of Pediatrics, 4200 Wisconsin Ave. # 200, Washington, DC, 20016, USA.
Diagn Microbiol Infect Dis. 2020 Jan;96(1):114914. doi: 10.1016/j.diagmicrobio.2019.114914. Epub 2019 Nov 5.
Russia introduced PCV13 in 2014. We studied the serotype composition of S. pneumoniae isolated from the nasopharynx of healthy children younger than 6 years in St. Petersburg, Smolensk, Perm, Krasnoyarsk, Khanty-Mansiysk and Khabarovsk, between 2016 and 2018. 2.4% of children had completed a 3-dose course of PCV13, while 25.6% had received 1 or 2 doses. Pneumococcal DNA detection by PCR demonstrated S. pneumoniae in 37.2% of samples with regional variation between sites (27.3 to 56.9%). There was little difference between vaccinated, partially vaccinated and un-vaccinated children. Children who had received at least 1 dose of PCV13 had lower carriage rates of vaccine serotypes than their unvaccinated peers (49.9 vs. 61.4%; p < 0.001). Children who had received at least 1 dose of PCV13 showed increased carriage rates of non-vaccine serotypes (50 vs 38.6%; P < 0.001). Especially serogroup 15AF was more prevalent among fully immunized children than among their peers (12.5 vs 2.7%; P < 0.05).
俄罗斯于 2014 年引入了 PCV13。我们研究了 2016 年至 2018 年期间，圣彼得堡、斯摩棱斯克、彼尔姆、克拉斯诺亚尔斯克、汉特-曼西斯克和哈巴罗夫斯克地区 6 岁以下健康儿童鼻咽分离的肺炎链球菌血清型构成。2.4%的儿童完成了 3 剂 PCV13 接种，25.6%的儿童接种了 1 剂或 2 剂。PCR 检测肺炎链球菌 DNA 显示，37.2%的样本中存在肺炎链球菌，不同地区之间存在差异（27.3%至 56.9%）。疫苗接种、部分接种和未接种儿童之间差异不大。至少接种 1 剂 PCV13 的儿童的疫苗血清型携带率低于未接种疫苗的儿童（49.9%比 61.4%；p<0.001）。至少接种 1 剂 PCV13 的儿童携带非疫苗血清型的比率增加（50%比 38.6%；P<0.001）。特别是 15 群 A 血清型在完全免疫接种的儿童中比在未接种疫苗的儿童中更为常见（12.5%比 2.7%；P<0.05）。
