Foot and Ankle Specialists of the Mid-Atlantic, LLC., Rockville, MD, U.S.A.
Anticancer Res. 2019 Nov;39(11):6175-6181. doi: 10.21873/anticanres.13825.
BACKGROUND/AIM: Acral lentiginous melanoma (ALM) is a rare entity on the foot. This study aimed to reveal its clinical presentations, histopathology and treatment options.
Seven cases of ALM involving foot were treated in our Institute in a 3-year period.
The patients' age ranged from 38 to 84 years, with a mean of 65. The ratios of males to females and white to non-white were 4:3 and 5:2, respectively. Clinically, ALM presented as asymmetric, irregular shaped, black-brown, variegatedly discolored, papular, verrucoid, ulcerated or nodular lesions with or without pain. All ALMs were treated with either wide local excision (WLE) or toe amputation. Histologically, ALM was characterized by multiple single and nested atypical melanocytes growing along the dermal-epidermal junction, and extending into dermal layer in nodular growth pattern.
ALM is a rare, asymmetric, irregularly bordered, variegatedly pigmented lesion. WLE or toe amputation is the standard treatment option.
背景/目的：肢端雀斑样黑素瘤（ALM）是一种罕见的足部疾病。本研究旨在揭示其临床表现、组织病理学和治疗选择。
在 3 年期间，我们研究所治疗了 7 例涉及足部的 ALM 病例。
患者年龄为 38 至 84 岁，平均年龄为 65 岁。男性与女性的比例以及白人与非白人的比例分别为 4:3 和 5:2。临床上，ALM 表现为不对称、不规则形状、黑褐色、斑驳变色、丘疹、疣状、溃疡性或结节性病变，伴有或不伴有疼痛。所有 ALM 均采用广泛局部切除（WLE）或趾截肢治疗。组织学上，ALM 的特征是多个单一和嵌套的不典型黑素细胞沿着表皮-真皮交界处生长，并以结节生长模式延伸到真皮层。
ALM 是一种罕见的、不对称的、不规则边界的、斑驳色素沉着的病变。WLE 或趾截肢是标准的治疗选择。
